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Monday, April 27, 2020 | History

4 edition of Bioassay of chloropicrin for possible carcinogenicity. found in the catalog.

Bioassay of chloropicrin for possible carcinogenicity.

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  • 31 Currently reading

Published by Dept. of Health, Education, and Welfare, Public Health Service, National Institutes of Health, National Cancer Institute, Division of Cancer Cause and Prevention, Carcinogenesis Testing Program in Bethesda, Md .
Written in English

    Subjects:
  • Carcinogens.,
  • Chloropicrin -- Toxicology.,
  • Pesticides -- Toxicology.

  • Edition Notes

    SeriesCarcinogenesis technical report series ; no. 65, DHEW publication ; no. (NIH) 78-1315, DHEW publication -- no. (NIH) 78-1315.
    The Physical Object
    Pagination86 p. in various pagings :
    Number of Pages86
    ID Numbers
    Open LibraryOL15221001M

    Bioassays Bioassays are experiments that use living things to test the toxicity of chemicals. Students can use bioassays to conduct a wide range of experiments relating to toxicity of known chemical solutions or unknown mixtures such as samples of water, sediment, or soil from the environment.   Chloropicrin is a soil fumigant used for its broad biocidal and fungicidal properties, primarily in high-value crops such as strawberries, peppers, onions, tobacco, flowers, tomatoes, and nursery crops. John Stenhouse, a Scottish chemist and inventor, synthesized chloropicrin in Chloropicrin definition is - a colorless liquid CCl3NO2 that causes tears and vomiting and is used especially as a soil fumigant. For immediate release: Aug Contact: Paul Towers, PAN, Sarah Aird, CPR, Scientists Say Officials Ignored Science of Pesticide Linked to CancerAdvocates deliver o petitions urging officials to follow science, develop better health protections, and promote pesticide alternatives in California’s strawberry fields.


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Bioassay of chloropicrin for possible carcinogenicity. by National Cancer Institute (U.S.). Division of Cancer Cause and Prevention. Download PDF EPUB FB2

Bioassay of chloropicrin for possible carcinogenicity (OCoLC) Bioassay of chloropicrin for possible carcinogenicity. book Type: Government publication, National government publication: Document Type: Book: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. OCLC Number: Notes: "CAS no. " Description. Bioassay of chloropicrin for possible carcinogenicity (OCoLC) Material Type: Document, Government publication, National government publication, Internet resource: Document Type: Internet Resource, Computer File: All Authors / Contributors: National Cancer Institute (U.S.).

Division of Cancer Cause and Prevention. A bioassay of p-cresidine for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice. p-Cresidine was administered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.

The dietary concentrations used in the chronic bioassay for low and high dose rats were and CAS no. Pages: National Institutes of Health.

Bioassay of Chloropicrin for Possible Carcinogenicity. NCI Technical Report No. 65, DHEW Publication No. (NIH) Secara, S.R. Chloropicrin - Octanol/Water Partition Coefficient.

Bolsa Research Associates Inc. Hollister, CA. Chloropicrin is a C-nitro compound Bioassay of chloropicrin for possible carcinogenicity. book is nitromethane in which all three hydrogens are replaced by chlorines.

It is a severe irritant, and can cause immediate, severe inflammation of the eyes, nose and throat, and significant injuries to the upper and lower respiratory tract. Formerly stockpiled as a chemical warfare agent, it has been widely.

Bioassay of chloropicrin for possible carcinogenicity. book. Chloropicrin's chemical formula is CCl 3 NO 2 and its molecular weight is grams/mole.

Pure chloropicrin is a colorless liquid, with a boiling point of °C. Chloropicrin is sparingly soluble in water with solubility of mg/L at 25 °C. It is volatile, with a vapor pressure of millimeters of mercury (mmHg) at 25 °C; the corresponding Henry's law constant is 0 Chemical formula: CCl₃NO₂.

The symptoms of chloropicrin depend on the mode of exposure. Very low concentrations cause a burning sensation of the eyes, which may serve as a warning. Clinical signs by mode of exposure are listed in Table Initial management.

The casualty must be removed from further exposure and decontaminated as soon as possible. CHLOROPICRIN Emergency Phone: Dow AgroSciences LLC Indianapolis, IN Effective Date: 7/22/99 Product Code: MSDS: 3 7. HANDLING AND STORAGE: PRECAUTIONS TO BE TAKEN IN HANDLING AND STORAGE: Avoid any possible contact with Bioassay of chloropicrin for possible carcinogenicity.

book or vapor. Measure chloropicrin concentration with a Matheson-Kitagawa detection device File Size: 32KB. Chloropicrin is relatively inert chemically and non-corrosive to copper, brass, and bronze; but it attacks iron, zinc, and other light metals.

Contact with metals may evolve flammable hydrogen gas. Chloropicrin reacts violently with aniline, sodium methoxide, and propargyl bromide. It also reacts with 2-bromopropyne and strong oxidants.

BIOASSAY OF DICHLORVOS. FOR POSSIBLE CARCINOGENICITY. Carcinogen Bioassay and Program Resources Branch Carcinogenesis Program Division of Cancer Cause and Prevention National Cancer Institute National Institutes of Health Bethesda, Maryland DHEW Publication No.

(NIH) 77 File Size: 3MB. Long-term animal bioassays for carcinogenicity are used regularly to determine whether chemical agents are capable of inducing cancer in exposed animals. Two important aspects of current bioassays are that testing covers a substantial portion of the lifespan of the test species and that high doses.

Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay. carcinogenicity bioassay in the Bioassay of chloropicrin for possible carcinogenicity. book literature and the potential for the possible incorporation of alternative tests.

A bioassay of p-cresidine for possible carcinogenicity was con­ ducted using Fischer rats and B6C3F1 mice. p-Cresidine was ad­ ministered in the feed, at either of two concentrations, to groups of 50 male and 50 female animals of each species.

The dietary con­ centrations used in File Size: 3MB. Questions and Answers on Chloropicrin. The pest management industry in the United States relies on fumigation with Vikane gas fumigant to eliminate drywood termites, bed bugs, and other pests that infest and damage residences, businesses, historic sites, and other structures.

Vikane is a colorless, odorless, tasteless gas and is non-detectable. Bioassay of ICRF for possible carcinogenicity Published: () Bioassay of sulfisoxazole for possible carcinogenicity Published: () Bioassay of estradiol mustard for possible carcinogenicity Published: ().

NTP. Chloropicrin (). Chemical Effects in Biological Systems (CEBS). Research Triangle Park, NC (USA): National Toxicology Program (NTP). Accessed https://manti. A bioassay of technical-grade hydrazobenzene for possible carcinogenicity was conducted using Fischer rats and B6C3F1 mice.

Hydrazobenzene was administered in the feed, at either of two concentrations, to groups of 50 male and 47 to 50 females animals of each species.

Some chloropicrin end-use products are packaged as % chloropicrin, while other products contain mixtures of chloropicrin with methyl bromide, 1,3-D, and iodomethane. In these combination products the percent active ingredient for chloropicrin ranges from % when combined with methyl bromide, % when combined with 1,3-D, and % whenFile Size: 1MB.

Bioassay of piperonyl butoxide for possible carcinogenicity Published: () Bioassays of DDT, TDE, and p, p'-DDE for possible carcinogenicity Published: () Bioassay of dixathion for possible carcinogenicity Published: (). carcinogenicity studies are caused by a non-genotoxic mechanism for which rodents are particularly sensitive, i.e.: continuous release of calcitonin due to persistent File Size: KB.

BIOASSAY OF FLUOMETURON FOR POSSIBLE CARCINOGENICITY CAS No. NCI-CG-TR NTP U.S. DEPARTMENT OF HEALTH AND HUMAN SERVICES Public Health Service National Institutes of Health. BIQASSAY OF FLUOMETURDN FOR POSSIBLE CARCINOGENICITY Carcinogenesis Testing Program. CTAs are faster and more cost efficient than the in vivo rodent carcinogenicity assay, providing a useful approach for screening of chemicals with respect to their carcinogenic : Romualdo Benigni.

Pesticide properties for chloropicrin, including approvals, environmental fate, eco-toxicity and human health issues. Chloropicrin is used most often as a mixture with MB or 1,3-D. However there are some applications of CP as the sole fumigant.

However there are some applications of CP as the sole fumigant. The application methods for CP are the same methods as for MB and 1,3-D, but the AF values are unique to CP (Barry et al., ). New York, NY: McGraw-Hill Book Company, Inc., p.

Ritlop B []. Das todlicehkeitsprodukt des chlorpikrins. Zeit Ges Exp Med (in German). Sangyo Igaku (Japanese Journal of Industrial Health) []. Inhalation toxicity of phosgene and trichloronitromethane (chloropicrin). (in Japanese). Sine C, ed. [ Chloropicrin (Cl3CNO2), toxic organic compound used alone or in combination with methyl bromide as a soil fumigant and fungicide.

Chloropicrin has a boiling point of °C ( °F). Its vapours are irritating to the skin, eyes, and upper respiratory tract, and it has been used in chemical warfare.

CHLOROPICRIN is a powerful irritant affecting all body surfaces, more toxic then chlorine. It can be shocked into detonation. When heated to decomposition, it emits highly toxic fumes of chlorine gas and nitrogen oxides [Sax, 9th ed.,p.

CHAPTER 8 BIOASSAY PROCEDURES BIOASSAY a. Bioassays are procedures which estimate the amount of radioactive material deposited in the body, either by direct measurement, using sensitive x-ray detectors placed over the chest (lung counting) and/ or other organs, or by detection of radioactivity in the excreta (feces and urine).File Size: 61KB.

Unfortunately, this book can't be printed from the OpenBook. If you need to print pages from this book, we recommend downloading it as a PDF. Visit to get more information about this book, to buy it in print, or to download it as a free PDF.

Environmentally, chloropicrin does not have a significant ozone depletion potential because it undergoes rapid breakdown in sunlight.

It is metabolized in soil to carbon dioxide. In a plant metabolism study utilizing soil treated with it, no chloropicrin or nitromethane was detected in any plant tissue or.

Abstract: Carcinogenicity and Chronic Toxicity in Rats and Mice Exposed by Inhalation to 1,2-Dichloroethane for Two Years: Kasuke NAGANO, et al.

Japan Bioassay Research Center, Japan Industrial Safety and Health Association— Carcinogenicity and chronic toxicity of 1,2-dichloroethane (DCE) were examined by inhalation. () National Institutes of Health. Bioassay of Chloropicrin for Possible Carcinogenicity.

NCI Technical Report No. 65, DHEW Publication No. (NIH) () Secara, S.R. Chloropicrin - Octanol/Water Partition Coefficient. Bolsa Research Associates Inc.

Hollister, CA. (Unpublished study submitted to USEPA). Chloropicrin is produced by the chlorination of picric acid and its salts. The minimal active concentration of chloropicrin is mg/liter, and the intolerable concentration, mg/liter (for 2 min); in large concentrations, it has an asphyxiating effect.

Chloropicrin was used as. After the chloropicrin has been applied, the holes are immediately plugged • Approximately 10 million pounds of chloropicrin are used annually for pre-plant soil fumigations.

Health Effects & Risks Health Effects • Chloropicrin can cause eye, nose, throat, and upper respiratory irritation. Results from a chloropicrin human sensory irritationFile Size: KB. Chloropicrin is not sprayed or applied to crops; it is a clear liquid that is injected into the soil before crops are planted to rid the soil of pests and soil-borne diseases.

This week the state is convening a Soil Health Symposium at UC-Davis to address the critical need for clean soil. I applaud that effort. Animal Carcinogenicity Studies: 3. Alternatives to the Bioassay Andrew Knight,1 Jarrod Bailey2 and Jonathan Balcombe3 1Animal Consultants International, London, UK; 2School of Population and Health Sciences, Faculty of Medical Sciences, University of Newcastle upon Tyne, Newcastle upon Tyne, UK; 3Physicians Committee for.

Glyphosate toxicity and carcinogenicity: a review of the scientific explores possible reasons for the different conclusions, with a focus on the EU assessment, as this is the evaluation in carcinogenicity hazard identification as a case study—and,Cited by: Chloropicrin is a skin and eye irritant and lacrymator causing irritation at concentrations as low as ppm in humans, depending on individual susceptibility.

A concentration of 15 ppm could not be tolerated by any of the test subjects. Chloropicrin causes irritation of upper respiratory passages followed by edema and pneumonia. Chloropicrin Information about Chloropicrin is for educational purposes only. ALS Environmental provides no warranty, expressed or implied, as to the accuracy, reliability or completeness of furnished data.

ALS Environmental is a laboratory testing network and is not affiliated with the U.S. Department of Transportation, the Emergency Response.

The project is made possible by our Pdf and by PAN general funds. We need your support to maintain and improve this system. including carcinogenicity, reproductive and developmental toxicity, neurotoxicity, and acute toxicity. Regulatory.

Any underlined term with a book .CHLOROPICRIN Novem CHLOROPICRIN. SUMMARY. Chloropicrin (trichloronitromethane) was first patented for use as an insecticide in Chloropicrin is a broad-spectrum fumigant with insecticidal, fungicidal, nematicidal and herbicidal properties.

Chloropicrin also has a low odor threshold and causes sensory irritation at.Notes ebook physician: Chloropicrin can cause irritation of the mucous membrane and upper respiratory tract. Inhalation may cause anemia, weak and irregular heart, recurrent asthmatic attacks, bronchitis, pulmonary edema, and possible death.

Gastrointestinal irritation with nausea, vomiting and diarrhea. Ingestion may cause colic and death.